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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM148142
Substrate
n/a
Meas. Tech.
FRET Assay
IC50
1±n/a nM
Citation
 Christopher, MP; Fradera Llinas, FX; Machacek, M; Martinez, M; Reutershan, MH; Shizuka, M; Sun, B; Thompson, CF; Trotter, BW; Voss, ME; Altman, MD; Bogen, SL; Doll, RJ Substituted imidazopyridines as HDM2 inhibitors US Patent  US8962611 Publication Date 2/24/2015 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM148142
Synonyms:
US8962611, 3.91
Type:
Small organic molecule
Emp. Form.:
C28H34ClN7O3
Mol. Mass.:
552.068
SMILES:
CC(C)[C@@H]1C[C@@H](O)CN1c1nc2cc(nc(-c3cncc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1)-c1noc(=O)[nH]1 |r,wU:26.29,5.5,wD:3.2,29.33,(4.19,4.55,;3.42,3.21,;1.94,3.61,;4.19,1.88,;5.66,1.41,;5.66,-.13,;6.99,-.9,;4.19,-.61,;3.29,.64,;1.75,.64,;.84,1.88,;-.62,1.41,;-1.95,2.18,;-3.29,1.41,;-3.29,-.13,;-1.95,-.9,;-1.95,-2.44,;-.62,-3.21,;-.62,-4.75,;-1.95,-5.52,;-3.29,-4.75,;-4.62,-5.52,;-3.29,-3.21,;-.62,-.13,;.84,-.61,;.84,-2.15,;2.18,-2.92,;3.51,-2.15,;4.84,-2.92,;4.84,-4.46,;6.18,-5.23,;3.51,-5.23,;2.18,-4.46,;-4.62,2.18,;-6.09,1.7,;-6.99,2.95,;-6.09,4.19,;-6.86,5.52,;-4.62,3.72,)|
Structure:
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