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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151879
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151879
Synonyms:
US8987457, 73
Type:
Small organic molecule
Emp. Form.:
C28H31F3N4O4S
Mol. Mass.:
576.63
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F |r,wU:3.15,5.5,1.0,7.8,(-.67,.87,;-2,.1,;-2,-1.44,;-3.33,-2.21,;-4.67,-1.44,;-4.67,.1,;-6,.87,;-3.33,.87,;-3.33,2.41,;-2,3.18,;-2,4.72,;-.67,5.49,;.67,6.26,;-1.44,6.83,;.1,4.16,;-3.33,-3.75,;-4.67,-4.52,;-4.67,-6.06,;-3.33,-6.83,;-2,-6.06,;-2,-4.52,;-.67,-3.75,;.67,-4.52,;.67,-6.06,;2,-3.75,;3.33,-4.52,;4.67,-3.75,;4.67,-2.21,;6,-1.44,;3.33,-1.44,;2,-2.21,;3.33,.1,;2,.87,;.67,.1,;2,2.41,;3.33,3.18,;3.33,4.72,;4.67,2.41,;4.67,.87,;6,.1,)|
Structure:
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