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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151936
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.03±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151936
Synonyms:
US8987457, 130
Type:
Small organic molecule
Emp. Form.:
C30H35F3N4O6S
Mol. Mass.:
636.682
SMILES:
COCCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1 |r,wU:29.31,31.34,41.44,33.36,(8,4.62,;6.67,5.39,;5.33,4.62,;4,5.39,;2.67,4.62,;2.67,3.08,;1.33,2.31,;1.33,.77,;;2.67,,;4,.77,;5.33,,;4,2.31,;2.67,-1.54,;1.33,-2.31,;1.33,-3.85,;2.67,-4.62,;4,-3.85,;4,-2.31,;5.33,-1.54,;,-4.62,;,-6.16,;-1.33,-3.85,;-2.67,-4.62,;-2.67,-6.16,;-4,-6.93,;-5.33,-6.16,;-5.33,-4.62,;-4,-3.85,;-4,-2.31,;-2.67,-1.54,;-2.67,,;-1.33,.77,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-6.67,5.39,;-6.67,6.93,;-7.44,4.06,;-8,6.16,;-5.33,,;-6.67,.77,;-5.33,-1.54,)|
Structure:
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