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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151944
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.03±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151944
Synonyms:
US8987457, 138
Type:
Small organic molecule
Emp. Form.:
C29H31F3N4O3
Mol. Mass.:
540.5766
SMILES:
CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1 |r,wU:6.10,3.3,8.9,wD:2.1,(-4.67,3.15,;-3.33,2.38,;-3.33,.84,;-2,.07,;-.67,.84,;-2,-1.47,;-3.33,-2.24,;-4.67,-1.47,;-4.67,.07,;-6,.84,;-3.33,-3.78,;-4.67,-4.55,;-4.67,-6.09,;-3.33,-6.86,;-2,-6.09,;-2,-4.55,;-.67,-3.78,;.67,-4.55,;.67,-6.09,;2,-3.78,;3.33,-4.55,;4.67,-3.78,;4.67,-2.24,;6,-1.47,;3.33,-1.47,;2,-2.24,;3.33,.07,;2,.84,;.67,.07,;2,2.38,;3.33,3.15,;4.67,2.38,;4.67,.84,;6,.07,;3.33,4.69,;4.67,3.92,;4.42,5.78,;3.33,6.86,;2.25,5.78,)|
Structure:
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