Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151947
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151947
Synonyms:
US8987457, 141
Type:
Small organic molecule
Emp. Form.:
C30H35F3N4O5S
Mol. Mass.:
620.683
SMILES:
CC(C)Oc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCS(C)(=O)=O)[C@H](N)C1 |r,wU:28.30,30.33,40.43,32.35,(6,6.93,;6,5.39,;7.34,4.62,;4.67,4.62,;4.67,3.08,;3.33,2.31,;3.33,.77,;2,,;4.67,,;6,.77,;7.34,,;6,2.31,;4.67,-1.54,;3.33,-2.31,;3.33,-3.85,;4.67,-4.62,;6,-3.85,;6,-2.31,;7.34,-1.54,;2,-4.62,;2,-6.16,;.67,-3.85,;-.67,-4.62,;-.67,-6.16,;-2,-6.93,;-3.33,-6.16,;-3.33,-4.62,;-2,-3.85,;-2,-2.31,;-.67,-1.54,;-.67,,;.67,.77,;-2,.77,;-2,2.31,;-3.33,3.08,;-4.67,2.31,;-6,3.08,;-6.77,1.75,;-7.34,3.85,;-5.23,4.41,;-3.33,,;-4.67,.77,;-3.33,-1.54,)|
Structure:
Search PDB for entries with ligand similarity: