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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151953
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.03±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151953
Synonyms:
US8987457, 147
Type:
Small organic molecule
Emp. Form.:
C28H29F3N8O2
Mol. Mass.:
566.5775
SMILES:
CC(C)Oc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1 |r,wU:30.33,33.36,32.39,(4.02,7.06,;4.42,5.58,;5.91,5.18,;3.33,4.49,;3.33,2.95,;2,2.18,;2,.64,;.67,-.13,;3.33,-.13,;4.67,.64,;6,-.13,;4.67,2.18,;3.33,-1.67,;2,-2.44,;2,-3.98,;3.33,-4.75,;4.67,-3.98,;4.67,-2.44,;6,-1.67,;.67,-4.75,;.67,-6.29,;-.67,-3.98,;-2,-4.75,;-2,-6.29,;-3.33,-7.06,;-4.67,-6.29,;-4.67,-4.75,;-3.33,-3.98,;-3.33,-2.44,;-2,-1.67,;-2,-.13,;-.67,.64,;-3.33,.64,;-4.67,-.13,;-6,.64,;-4.67,-1.67,;-3.33,2.18,;-4.58,3.08,;-4.1,4.55,;-2.56,4.55,;-2.09,3.08,)|
Structure:
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