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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151959
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.01±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151959
Synonyms:
US8987457, 153
Type:
Small organic molecule
Emp. Form.:
C32H33F4N5O3
Mol. Mass.:
611.6297
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(F)CCOCC1 |r,wU:3.13,1.0,5.5,7.8,(,.38,;-1.33,-.38,;-1.33,-1.93,;-2.67,-2.69,;-4,-1.93,;-4,-.38,;-5.33,.38,;-2.67,.38,;-2.67,1.93,;-4,2.69,;-4,4.23,;-5.33,5,;-6.67,5.78,;-2.67,-4.23,;-4,-5,;-4,-6.54,;-2.67,-7.31,;-1.33,-6.54,;-1.33,-5,;,-4.23,;1.33,-5,;1.33,-6.54,;2.67,-4.23,;4,-5,;5.33,-4.23,;5.33,-2.69,;6.67,-1.92,;4,-1.93,;2.67,-2.69,;4,-.38,;2.67,.38,;1.33,-.38,;2.67,1.93,;4,2.69,;5.33,1.93,;5.33,.38,;6.67,-.38,;4,4.23,;5.33,3.47,;5.33,5,;5.33,6.54,;4,7.31,;2.67,6.54,;2.67,5,)|
Structure:
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