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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151965
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151965
Synonyms:
US8987457, 159
Type:
Small organic molecule
Emp. Form.:
C30H33F3N6O5
Mol. Mass.:
614.6154
SMILES:
COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F |r,wU:6.6,11.12,5.4,(-7.17,3.7,;-6.08,2.62,;-4.59,3.01,;-4.19,4.5,;-3.5,1.93,;-3.5,.38,;-2.17,-.38,;-.83,.38,;-2.17,-1.93,;-3.5,-2.69,;-4.84,-1.93,;-4.84,-.38,;-6.17,.38,;-3.5,-4.23,;-4.84,-5,;-4.84,-6.54,;-3.5,-7.31,;-2.17,-6.54,;-2.17,-5,;-.83,-4.23,;.5,-5,;.5,-6.54,;1.83,-4.23,;3.17,-5,;4.5,-4.23,;4.5,-2.69,;5.83,-1.92,;3.17,-1.93,;1.83,-2.69,;3.17,-.38,;1.83,.38,;.5,-.38,;1.83,1.93,;3.17,2.69,;3.17,4.23,;4.5,5,;5.83,4.24,;7.17,5,;7.17,6.54,;5.83,7.31,;4.5,6.54,;4.5,1.93,;4.5,.38,;5.83,-.38,)|
Structure:
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