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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151971
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151971
Synonyms:
US8987457, 165
Type:
Small organic molecule
Emp. Form.:
C28H28F3N5O3
Mol. Mass.:
539.5488
SMILES:
COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)[C@H](OCCC#N)[C@H](N)C1 |r,wU:26.28,28.31,36.39,30.33,(4.67,5.78,;3.33,5,;3.33,3.47,;2,2.69,;2,1.15,;.67,.38,;3.33,.38,;4.67,1.15,;6,.38,;4.67,2.69,;3.33,-1.15,;2,-1.93,;2,-3.47,;3.33,-4.23,;4.67,-3.47,;4.67,-1.93,;6,-1.15,;.67,-4.23,;.67,-5.78,;-.67,-3.47,;-2,-4.23,;-2,-5.78,;-3.33,-6.54,;-4.67,-5.78,;-4.67,-4.23,;-3.33,-3.47,;-3.33,-1.93,;-2,-1.15,;-2,.38,;-.67,1.15,;-3.33,1.15,;-3.33,2.69,;-2,3.47,;-2,5,;-.67,5.78,;.67,6.54,;-4.67,.38,;-6,1.15,;-4.67,-1.15,)|
Structure:
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