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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151990
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151990
Synonyms:
US8987457, 184
Type:
Small organic molecule
Emp. Form.:
C31H32F3N5O3
Mol. Mass.:
579.6127
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1 |r,wU:3.13,1.0,5.5,7.8,(,.84,;-1.33,.07,;-1.33,-1.47,;-2.67,-2.24,;-4,-1.47,;-4,.07,;-5.33,.84,;-2.67,.84,;-2.67,2.38,;-4,3.15,;-4,4.69,;-5.33,5.46,;-6.67,6.23,;-2.67,-3.78,;-4,-4.55,;-4,-6.09,;-2.67,-6.86,;-1.33,-6.09,;-1.33,-4.55,;,-3.78,;1.33,-4.55,;1.33,-6.09,;2.67,-3.78,;4,-4.55,;5.33,-3.78,;5.33,-2.24,;6.67,-1.47,;4,-1.47,;2.67,-2.24,;4,.07,;2.67,.84,;1.33,.07,;2.67,2.38,;4,3.15,;5.33,2.38,;5.33,.84,;6.67,.07,;4,4.69,;5.33,3.92,;5.09,5.77,;4,6.86,;2.91,5.77,)|
Structure:
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