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Target
Thymidine phosphorylase
Ligand
BDBM152490
Substrate
n/a
Meas. Tech.
Thymidine Phosphorylase Inhibition Assay
pH
7.4±n/a
IC50
6.343e+4± 9.2e+2 nM
Comments
extracted
Citation
 Shahzad, SA; Yar, M; Bajda, M; Shahzadi, L; Khan, ZA; Naqvi, SA; Mutahir, S; Mahmood, N; Khan, KM Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives. Bioorg Chem 60:37-41 (2015) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECO57 | Thymidine phosphorylase (TP) | deoA
Type:
Protein
Mol. Mass.:
47171.52
Organism:
Escherichia coli (Enterobacteria)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM152490
Synonyms:
5-(3',4',5'-Trimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione (8)
Type:
Small organic molecule
Emp. Form.:
C11H12N2O4S
Mol. Mass.:
268.289
SMILES:
COc1cc(cc(OC)c1OC)-c1n[nH]c(=S)o1
Structure:
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