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Target
Mitogen-activated protein kinase kinase kinase 14
Ligand
BDBM158864
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Ki
7±n/a nM
Comments
extracted
Citation
 Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent  US9034866 Publication Date 5/19/2015 
Target
Name:
Mitogen-activated protein kinase kinase kinase 14
Synonyms:
HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK
Type:
Protein
Mol. Mass.:
104059.50
Organism:
Homo sapiens (Human)
Description:
Q99558
Residue:
947
Sequence:
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
  
Inhibitor
Name:
BDBM158864
Synonyms:
US9034866, 339
Type:
Small organic molecule
Emp. Form.:
C22H22FN3O4
Mol. Mass.:
411.4262
SMILES:
CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)c(n3C3CC(C3)c2cc1F)C1(O)COC1 |(7.54,-.05,;6.21,.72,;7.54,1.49,;6.21,2.26,;4.88,-.05,;3.54,-.82,;2.21,-1.59,;.88,-.82,;-.46,-1.59,;-1.66,-.63,;-1.52,.91,;-2.94,1.51,;-3.34,3,;-4.83,3.4,;-2.25,4.09,;-3.95,.35,;-3.16,-.97,;-3.83,-2.36,;-3.16,-3.75,;-1.66,-4.09,;-2.29,-2.36,;-.46,-3.13,;.88,-3.9,;2.21,-3.13,;3.54,-3.9,;-5.44,.75,;-5.04,-.74,;-6.21,2.08,;-7.54,1.31,;-6.77,-.02,)|
Structure:
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