Reaction Details Report a problem with these data
Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM166155
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.5±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent  US9067937 Publication Date 6/30/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM166155
Synonyms:
US9067937, 203
Type:
Small organic molecule
Emp. Form.:
C24H26Cl2N4O3
Mol. Mass.:
489.394
SMILES:
CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)CO |r,wU:6.9,wD:3.2,(-3.84,3.35,;-2.36,3.74,;-1.96,5.23,;-1.27,2.66,;-1.66,1.17,;-.58,.08,;.91,.48,;1.31,1.96,;.22,3.05,;2,-.61,;2,-2.15,;3.33,-2.92,;3.33,-4.46,;2,-5.23,;.67,-4.46,;-.67,-5.23,;-2,-4.46,;-2,-2.92,;-.67,-2.15,;.67,-2.92,;-3.33,-2.15,;-4.67,-2.92,;-6,-2.15,;-7.34,-2.92,;-6,-.61,;-7.34,.16,;-4.67,.16,;-4.67,1.7,;-3.33,-.61,;4.67,-2.15,;4.67,-.61,;6,-2.92,;7.34,-2.15,)|
Structure:
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