Reaction Details
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Report a problem with these dataTarget
Maternal embryonic leucine zipper kinase
Ligand
BDBM166156
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.3±n/a nM
Comments
extracted
Citation
Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 More Info.:
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Inhibitor
Name:
BDBM166156
Synonyms:
US9067937, 204
Type:
Small organic molecule
Emp. Form.:
C25H28ClFN4O3
Mol. Mass.:
486.966
SMILES:
CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(F)c(O)c(Cl)c1)C(=O)CO |r,wU:7.10,wD:4.3,(-3.05,5.78,;-1.96,4.69,;-.47,5.09,;-2.36,3.2,;-1.27,2.11,;-1.66,.62,;-.58,-.47,;.91,-.07,;1.31,1.42,;.22,2.51,;2,-1.16,;2,-2.7,;3.33,-3.47,;3.33,-5.01,;2,-5.78,;.67,-5.01,;-.67,-5.78,;-2,-5.01,;-2,-3.47,;-.67,-2.7,;.67,-3.47,;-3.33,-2.7,;-4.67,-3.47,;-6,-2.7,;-7.34,-3.47,;-6,-1.16,;-7.34,-.39,;-4.67,-.39,;-4.67,1.15,;-3.33,-1.16,;4.67,-2.7,;4.67,-1.16,;6,-3.47,;7.34,-2.7,)|
Structure:
