Reaction Details Report a problem with these data
Target
Reverse transcriptase protein
Ligand
BDBM175332
Substrate
n/a
Meas. Tech.
In-vitro HIV-1 RT Screening
IC50
3.696e+4±n/a nM
Citation
 Chander, S; Ashok, P; Zheng, YT; Wang, P; Raja, KS; Taneja, A; Murugesan, S Design, synthesis and in-vitro evaluation of novel tetrahydroquinoline carbamates as HIV-1 RT inhibitor and their antifungal activity. Bioorg Chem 64:66-73 (2016) [PubMed]  Article 
Target
Name:
Reverse transcriptase protein
Synonyms:
Gag-Pol polyprotein | HIV-1 Reverse transcriptase (HIV-1 RT) | Reverse Transcriptase (HIV-1 RT) | Reverse transcriptase (HIV1-RT)
Type:
Protein
Mol. Mass.:
30197.77
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Description:
Q9WJQ1
Residue:
259
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM175332
Synonyms:
1-(4-chlorophenyl)-2-(3,4-dihydroquinolin-1(2H)-yl)ethyl phenylcarbamate (6a)
Type:
Small organic molecule
Emp. Form.:
C24H23ClN2O2
Mol. Mass.:
406.905
SMILES:
Clc1ccc(cc1)C(CN1CCCc2ccccc12)OC(=O)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: