Reaction Details Report a problem with these data
Target
Maternal embryonic leucine zipper kinase
Ligand
BDBM177019
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
19±n/a nM
Comments
extracted
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent  US9120749 Publication Date 9/1/2015 
Target
Name:
Maternal embryonic leucine zipper kinase
Synonyms:
KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:
Enzyme
Mol. Mass.:
74665.45
Organism:
Homo sapiens (Human)
Description:
Q14680
Residue:
651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
  
Inhibitor
Name:
BDBM177019
Synonyms:
US9120749, 385
Type:
Small organic molecule
Emp. Form.:
C31H38ClN3O2
Mol. Mass.:
520.105
SMILES:
CCN(CC)C1CCC(CC1)Nc1c(cnc2ccc(cc12)-c1ccc(O)c(Cl)c1)C(=O)C1CCCC1 |(-5.45,3.89,;-4.36,2.8,;-2.87,3.2,;-2.47,4.69,;-3.56,5.78,;-1.78,2.11,;-.3,2.51,;.79,1.42,;.39,-.07,;-1.09,-.47,;-2.18,.62,;1.48,-1.16,;1.48,-2.7,;2.82,-3.47,;2.82,-5.01,;1.48,-5.78,;.15,-5.01,;-1.18,-5.78,;-2.52,-5.01,;-2.52,-3.47,;-1.18,-2.7,;.15,-3.47,;-3.85,-2.7,;-5.19,-3.47,;-6.52,-2.7,;-6.52,-1.16,;-7.85,-.39,;-5.19,-.39,;-5.19,1.15,;-3.85,-1.16,;4.15,-2.7,;4.15,-1.16,;5.48,-3.47,;5.48,-5.01,;6.95,-5.48,;7.85,-4.24,;6.95,-2.99,)|
Structure:
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