Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM178000
Substrate
n/a
Meas. Tech.
Fluorometric Imaging Plate Reader (FLIPR) Asssay
IC50
68.9±n/a nM
Citation
 Jordan, A; Bedford, S; Burkhard, K; Yule, I; Poullennec, K Thienopyrimidine compounds US Patent  US9120807 Publication Date 9/1/2015 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM178000
Synonyms:
US9120807, 12
Type:
Small organic molecule
Emp. Form.:
C23H18N6OS2
Mol. Mass.:
458.559
SMILES:
O=C(c1cccs1)c1nc(NCc2cccnc2)nc2cc(NCc3cccnc3)sc12
Structure:
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