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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM180715
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.57±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM180715
Synonyms:
US8829029, 15
Type:
Small organic molecule
Emp. Form.:
C29H34FN3O4
Mol. Mass.:
507.5964
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)C2COc3ccccc3O2)CC1 |r,wU:19.24,wD:16.17,(-5.25,-7.48,;-5.64,-5.99,;-4.56,-4.9,;-4.95,-3.41,;-6.44,-3.01,;-6.84,-1.53,;-8.33,-1.13,;-9.02,-3.7,;-7.53,-4.1,;-7.13,-5.59,;-5.75,-.44,;-4.26,-.84,;-3.17,.25,;-3.57,1.74,;-2.48,2.83,;-1,2.43,;.09,3.52,;1.58,3.12,;2.67,4.21,;2.27,5.7,;.78,6.1,;-.31,5.01,;3.36,6.79,;4.85,6.39,;5.94,7.48,;5.25,4.9,;4.16,3.81,;4.56,2.32,;6.04,1.93,;6.44,.44,;7.93,.04,;9.02,1.13,;8.62,2.62,;7.13,3.01,;6.73,4.5,;-5.06,2.14,;-6.15,1.05,)|
Structure:
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