Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM180753
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
5.132±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM180753
Synonyms:
US8829029, 48
Type:
Small organic molecule
Emp. Form.:
C26H31ClFN3O3S
Mol. Mass.:
520.059
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc(Cl)cc2)CC1 |r,wU:19.24,wD:16.17,(-8,-6.06,;-8,-4.52,;-6.67,-3.75,;-6.67,-2.21,;-8,-1.44,;-8,.1,;-9.34,.87,;-10.67,-1.44,;-9.34,-2.21,;-9.34,-3.75,;-6.67,.87,;-5.33,.1,;-4,.87,;-4,2.41,;-2.67,3.18,;-1.33,2.41,;,3.18,;1.33,2.41,;2.67,3.18,;2.67,4.72,;1.33,5.49,;,4.72,;4,5.49,;5.33,4.72,;6.1,6.06,;4.56,3.39,;6.67,3.95,;6.67,2.41,;8,1.64,;9.34,2.41,;10.67,1.64,;9.34,3.95,;8,4.72,;-5.33,3.18,;-6.67,2.41,)|
Structure:
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