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Target
D(3) dopamine receptor
Ligand
BDBM180730
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
3.861±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180730
Synonyms:
US8829029, 30
Type:
Small organic molecule
Emp. Form.:
C28H32FN3O4
Mol. Mass.:
493.5698
SMILES:
Fc1ccc2onc(C3CCN(CC[C@H]4CC[C@@H](CC4)NC(=O)c4ccc5OCOc5c4)CC3)c2c1 |r,wU:17.20,wD:14.13,(-2.81,-6.04,;-4.3,-5.64,;-5.39,-6.73,;-6.87,-6.33,;-7.27,-4.85,;-8.76,-4.45,;-8.07,-1.87,;-6.58,-2.27,;-5.49,-1.18,;-4.01,-1.58,;-2.92,-.49,;-3.32,1,;-2.23,2.09,;-.74,1.69,;.35,2.78,;1.84,2.38,;2.93,3.47,;2.53,4.95,;1.04,5.35,;-.05,4.26,;3.62,6.04,;5.1,5.64,;6.19,6.73,;5.5,4.16,;4.41,3.07,;4.81,1.58,;6.3,1.18,;7,-.19,;8.52,.05,;8.76,1.57,;7.39,2.27,;6.99,3.76,;-4.8,1.39,;-5.89,.31,;-6.18,-3.76,;-4.7,-4.16,)|
Structure:
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