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Target
D(3) dopamine receptor
Ligand
BDBM180735
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
3.708±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180735
Synonyms:
US8829029, 34B
Type:
Small organic molecule
Emp. Form.:
C27H38ClN3O3
Mol. Mass.:
488.062
SMILES:
Clc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)C[C@H]2CCCCO2)CC1 |r,wU:19.24,26.28,wD:16.17,(-8.67,3.46,;-7.34,4.23,;-6,3.46,;-4.67,4.23,;-4.67,5.77,;-3.33,6.54,;-3.33,8.08,;-6,8.08,;-6,6.54,;-7.34,5.77,;-2,5.77,;-.67,6.54,;.67,5.77,;.67,4.23,;2,3.47,;2,1.93,;3.33,1.16,;3.33,-.38,;4.67,-1.15,;6,-.38,;6,1.16,;4.67,1.93,;7.34,-1.15,;7.34,-2.69,;8.67,-3.46,;6,-3.46,;6,-5,;7.34,-5.77,;7.34,-7.31,;6,-8.08,;4.67,-7.31,;4.67,-5.77,;-.67,3.46,;-2,4.23,)|
Structure:
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