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Target
D(3) dopamine receptor
Ligand
BDBM180759
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
3.206±n/a nM
Citation
 Gobbi, L; Jaeschke, G; Roche, O; Sarmiento, RM; Steward, L Dual modulators of 5HT2A and D3 receptors US Patent  US8829029 Publication Date 9/9/2014 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM180759
Synonyms:
US8829029, 54
Type:
Small organic molecule
Emp. Form.:
C25H34ClN3O2
Mol. Mass.:
444.009
SMILES:
Clc1ccc2c(noc2c1)C1CCN(CC[C@H]2CC[C@@H](CC2)NC(=O)CC2CC2)CC1 |r,wU:19.24,wD:16.17,(-10.11,1.15,;-8.77,1.93,;-7.44,1.15,;-6.1,1.93,;-6.1,3.47,;-4.77,4.23,;-4.77,5.78,;-7.44,5.78,;-7.44,4.23,;-8.77,3.47,;-3.44,3.47,;-3.44,1.93,;-2.1,1.15,;-.77,1.93,;.56,1.16,;.56,-.38,;1.9,-1.15,;1.9,-2.69,;3.23,-3.47,;4.56,-2.69,;4.56,-1.15,;3.23,-.38,;5.9,-3.46,;5.9,-5,;4.56,-5.78,;7.23,-5.78,;8.57,-5,;10.11,-5,;9.34,-3.67,;-.77,3.47,;-2.1,4.24,)|
Structure:
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