Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM180853
Substrate
n/a
Meas. Tech.
CDK2/CycE Kinase Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
220±n/a nM
Comments
extracted
Citation
 Lücking, U; Kosemund, D; Scholz, A; Lienau, P; Siemeister, G; Bömer, U; Bohlmann, R Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group US Patent  US9133171 Publication Date 9/15/2015 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM180853
Synonyms:
US9133171, 58
Type:
Small organic molecule
Emp. Form.:
C21H19F2N5O2S
Mol. Mass.:
443.47
SMILES:
COc1cc(F)ccc1-c1nc(Nc2cc(C)cc(CS(C)(=O)=NC#N)c2)ncc1F
Structure:
Search PDB for entries with ligand similarity: