Reaction Details Report a problem with these data
Target
Alpha-ketoglutarate-dependent dioxygenase FTO [31-505]
Ligand
BDBM181057
Substrate
n/a
Meas. Tech.
In vitro Enzymatic Activity Assays
pH
7.5±n/a
Temperature
315.15±n/a K
IC50
3.924e+4±n/a nM
Comments
extracted
Citation
 Qiao, Y; Zhou, B; Zhang, M; Liu, W; Han, Z; Song, C; Yu, W; Yang, Q; Wang, R; Wang, S; Shi, S; Zhao, R; Chai, J; Chang, J A Novel Inhibitor of the Obesity-Related Protein FTO. Biochemistry 55:1516-22 (2016) [PubMed]  Article 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO [31-505]
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity associated protein (FTO) | KIAA1752
Type:
Protein
Mol. Mass.:
54550.55
Organism:
Homo sapiens (Human)
Description:
31-505aa used
Residue:
475
Sequence:
LTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM181057
Synonyms:
CHTB
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2O4
Mol. Mass.:
369.239
SMILES:
CC1(C)CC(C)(Oc2cc(O)c(Cl)cc12)c1cc(Cl)c(O)cc1O
Structure:
Search PDB for entries with ligand similarity: