Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase SYK
Ligand
BDBM182784
Substrate
n/a
Meas. Tech.
Syk Kinase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.37±n/a nM
Comments
extracted
Citation
 Sakamoto, T; Mita, T; Shibata, K; Ogino, Y; Komatani, H 1,2,4-triazine-6-carboxamide derivative US Patent  US9145414 Publication Date 9/29/2015 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM182784
Synonyms:
US9145414, 73
Type:
Small organic molecule
Emp. Form.:
C24H32N8O2
Mol. Mass.:
464.5633
SMILES:
N[C@H]1CCCC[C@H]1Nc1nnc(C(N)=O)c(Nc2cccc3n(ccc23)C2CC[C@H](O)CC2)n1 |r,wD:6.7,1.0,29.32,(5.88,1.29,;5.88,2.83,;7.21,3.6,;7.21,5.14,;5.88,5.91,;4.54,5.14,;4.54,3.6,;3.21,2.83,;1.87,3.6,;1.87,5.14,;.54,5.91,;-.79,5.14,;-2.13,5.91,;-3.46,5.14,;-2.13,7.45,;-.79,3.6,;-2.13,2.83,;-2.13,1.29,;-.79,.52,;-.79,-1.02,;-2.13,-1.79,;-3.46,-1.02,;-4.92,-1.5,;-5.83,-.25,;-4.92,.99,;-3.46,.52,;-5.32,-2.99,;-4.23,-4.07,;-4.63,-5.56,;-6.12,-5.96,;-6.52,-7.45,;-7.21,-4.87,;-6.81,-3.38,;.54,2.83,)|
Structure:
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