Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM182987
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7±n/a
IC50
8±n/a nM
Comments
extracted
Citation
 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application US Patent  US9150544 Publication Date 10/6/2015 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM182987
Synonyms:
US9150544, 21
Type:
Small organic molecule
Emp. Form.:
C24H27FN6O6S2
Mol. Mass.:
578.636
SMILES:
COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CC[C@@H](F)C2)C1=O)C(O)=O |r|
Structure:
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