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Target
Protein-glutamine gamma-glutamyltransferase 6
Ligand
BDBM185172
Substrate
n/a
Meas. Tech.
TG Activity Assays
IC50
>1.0e+4±n/a nM
Citation
 Badarau, E; Wang, Z; Rathbone, DL; Costanzi, A; Thibault, T; Murdoch, CE; El Alaoui, S; Bartkeviciute, M; Griffin, M Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions. Chem Biol 22:1347-61 (2015) [PubMed]  Article 
Target
Name:
Protein-glutamine gamma-glutamyltransferase 6
Synonyms:
Protein-glutamine gamma-glutamyltransferase 6 | TG6 | TGM3L | TGM3L_HUMAN | TGM6 | TGY | TGase Y | TGase-3-like | TGase-6 | Transglutaminase Y | Transglutaminase-3-like | Transglutaminase-6 | Transglutaminase-6 (TG6)
Type:
Protein
Mol. Mass.:
79319.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
706
Sequence:
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK
  
Inhibitor
Name:
BDBM185172
Synonyms:
[2-[[2-[4-(Adamantane-1-carbonyl)piperazin-1-yl]-2-oxo-ethyl]amino]-2-oxo-ethyl]-dimethyl-sulfonium bromide (1e)
Type:
Small organic molecule
Emp. Form.:
C21H34N3O3S
Mol. Mass.:
408.577
SMILES:
C[S+](C)CC(=O)NCC(=O)N1CCN(CC1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:21:22:26:20.25.19,25:20:27:24.26.23,25:24:27:21.20.19,THB:21:20:26:27.22.23|
Structure:
Search PDB for entries with ligand similarity: