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Target
Membrane primary amine oxidase
Ligand
BDBM185661
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±n/a
Temperature
303.15±n/a K
IC50
500±n/a nM
Comments
extracted
Citation
 Sayre, LM Amine oxidase inhibitors US Patent  US9161922 Publication Date 10/20/2015 
Target
Name:
Membrane primary amine oxidase
Synonyms:
AOC3 | AOC3_BOVIN | Plasma amine oxidase (BPAO)
Type:
Enzyme
Mol. Mass.:
84499.42
Organism:
Bos taurus (Bovine)
Description:
Q9TTK6
Residue:
763
Sequence:
MNQKTTLVLLALAVITIFALVCVLIAGRGGDGGEASQPHYCPSGTPSVQPWTHPGQNQLFADLSREELTAVMSFLTQKLGPDLVDAAQARPSDNCIFSVELQLPPKAAALAHLDRRSPPPAREALAIVFFGGQPQPNVTELVVGPLPQPSYMRDVTVERHGGPLPYYRRPVLLREYLDIDQMIFNRELPQAAGVLHHCCSYKQGGGNLVTMTTAPRGLQSGDRATWFGLYYNISGAGYYLHPVGLELLVDHKALDPAQWTIQKVFFQGRYYESLAQLEEQFEAGRVNVVVIPNNGTGGSWSLKSQVPPGPTPPLQFHPQGTRFSVQGSRVTSSLWTFSFGLGAFSGPRIFDIRFQGERLAYEISLQEAVAIYGGNTPAAMLTRYMDGCFGMGKFATPLTRGVDCPYLATYVDWHFLLESQAPRTLHDAFCVFEQNKGLPLRRHHSDFISQYFGGVVETVLVFRSVSTLLNYDYVWDMVFHPNGAIEVKFHATGYISSAFFFGTAQKYGNQVRENTLGTVHTHSAHYKVDLDVGGLENWVWAEDMAFVPTTVPWSPEHQIQRLQVTRKQLETEEQAAFPLGGASPRYLYLASKQSNKWGHPRGYRIQTVSFAGRPLPQNSSTERAISWGRYQLAVTQRKETEPSSSSVFNQNDPWTPTVDFADFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSINSADSIYFQKHQDAGSCEVNSLACLPKDPACAPDLPAFSHGGFFTN
  
Inhibitor
Name:
BDBM185661
Synonyms:
US9161922, Table 4, Compound 3
Type:
Small organic molecule
Emp. Form.:
C12H15N
Mol. Mass.:
173.2542
SMILES:
NCC=C=CCCc1ccccc1 |(5.2,1,;3.66,1,;2.89,-.33,;1.35,-.33,;-.19,-.33,;-.96,-1.67,;-2.5,-1.67,;-3.27,-3,;-4.81,-3,;-5.58,-4.33,;-4.81,-5.67,;-3.27,-5.67,;-2.5,-4.33,)|
Structure:
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