Reaction Details
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Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM185740
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
>20000±n/a nM
Citation
Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent US9162991 Publication Date 10/20/2015 More Info.:
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
TGM2 | TGM2_CAVCU | Transglutaminases (TGase)
Type:
Enzyme
Mol. Mass.:
77122.36
Organism:
Cavia cutleri (Guinea pig)
Description:
P08587
Residue:
690
Sequence:
MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA
Inhibitor
Name:
BDBM185740
Synonyms:
US9162991, 14a
Type:
Small organic molecule
Emp. Form.:
C15H10N4O4
Mol. Mass.:
310.2643
SMILES:
[O-]n1n[n+](C(=O)\C=C\c2ccc(cc2)[N+]([O-])=O)c2ccccc12
Structure:
