Reaction Details
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Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM185750
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
57000±7000 nM
Citation
Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent US9162991 Publication Date 10/20/2015 More Info.:
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
TGM2 | TGM2_CAVCU | Transglutaminases (TGase)
Type:
Enzyme
Mol. Mass.:
77122.36
Organism:
Cavia cutleri (Guinea pig)
Description:
P08587
Residue:
690
Sequence:
MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA
Inhibitor
Name:
BDBM185750
Synonyms:
US9162991, 26a
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3
Mol. Mass.:
344.3633
SMILES:
[O-][N+](=O)c1ccc(\C=C\C(=O)N2Cc3cccc4cccc(C2)c34)cc1
Structure:
