Reaction Details
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Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM185765
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
17000±1500 nM
Citation
Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent US9162991 Publication Date 10/20/2015 More Info.:
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
TGM2 | TGM2_CAVCU | Transglutaminases (TGase)
Type:
Enzyme
Mol. Mass.:
77122.36
Organism:
Cavia cutleri (Guinea pig)
Description:
P08587
Residue:
690
Sequence:
MAEDLILERCDLQLEVNGRDHRTADLCRERLVLRRGQPFWLTLHFEGRGYEAGVDTLTFNAVTGPDPSEEAGTMARFSLSSAVEGGTWSASAVDQQDSTVSLLLSTPADAPIGLYRLSLEASTGYQGSSFVLGHFILLYNPRCPADAVYMDSDQERQEYVLTQQGFIYQGSAKFINGIPWNFGQFEDGILDICLMLLDTNPKFLKNAGQDCSRRSRPVYVGRVVSAMVNCNDDQGVLQGRWDNNYSDGVSPMSWIGSVDILRRWKDYGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYFRNESGEIEGNKSEMIWNFHCWVESWMTRPDLEPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGHLNVKYDAPFVFAEVNADVVNWIRQKDGSLRKSINHLVVGLKISTKSVGRDEREDITHTYKYPEGSEEEREAFVRANHLNKLATKEEAQEETGVAMRIRVGQNMTMGSDFDIFAYITNGTAESHECQLLLCARIVSYNGVLGPVCSTNDLLNLTLDPFSENSIPLHILYEKYGDYLTESNLIKVRGLLIEPAANSYVLAERDIYLENPEIKIRVLGEPKQNRKLIAEVSLKNPLPVPLLGCIFTVEGAGLTKDQKSVEVPDPVEAGEQAKVRVDLLPTEVGLHKLVVNFECDKLKAVKGYRNVIIGPA
Inhibitor
Name:
BDBM185765
Synonyms:
US9162991, 4k
Type:
Small organic molecule
Emp. Form.:
C19H16N4O3
Mol. Mass.:
348.3553
SMILES:
CC(c1ccccc1)n1cc(nn1)C(=O)\C=C\c1ccc(cc1)N(=O)=O
Structure:
