Reaction Details
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Cell division cycle 7-related protein kinase
Ligand
BDBM50337330
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Ki
56.3±n/a nM
Comments
extracted
Citation
Akritopoulou-Zanze, I; Wakefield, BD; Mack, H; Turner, SC; Gasiecki, AF; Gracias, VJ; Sarris, KA; Kalvin, DM; Michmerhuizen, MJ; Shuai, Q; Patel, JR; Bakker, MH; Teusch, N; Johnson, EF; Kovar, PJ; Djuric, SW; Long, AJ; Vasudevan, A; George, DM; Wang, L; Li, B; Moore, NS; Hobson, AD; Woods, KW; Miyashiro, JM; Swann, Jr., SL; Penning, TD 5-substituted indazoles as kinase inhibitors US Patent US9163007 Publication Date 10/20/2015 More Info.:
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Inhibitor
Name:
BDBM50337330
Synonyms:
5-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole | CHEMBL1682352 | US9163007, 10
Type:
Small organic molecule
Emp. Form.:
C16H12FN5
Mol. Mass.:
293.2984
SMILES:
Fc1ccc(Cn2cc(nn2)-c2ccc3[nH]ncc3c2)cc1
Structure:
