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Target
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L]
Ligand
BDBM50438863
Substrate
n/a
Meas. Tech.
Recombinant TDP2 Assay
pH
7.5±n/a
IC50
170±n/a nM
Comments
extracted
Citation
 Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol 11:1925-33 (2016) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L]
Synonyms:
TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 mutant 9M(mTDP2 9M)
Type:
Protein
Mol. Mass.:
40804.32
Organism:
Mus musculus (Mouse)
Description:
The mTDP2 9M bears the mutations at residues Q278R, I281T, K282R, P318T, Y321C, E242G, S244A, R316G, and H323L.
Residue:
370
Sequence:
MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTRGHAAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDREVTRCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLGITAACKLRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
  
Inhibitor
Name:
BDBM50438863
Synonyms:
10-(4-Hydroxyphenyl)-2,4-dioxo-pyrimido[4,5-b]quinoline-8-carbonitrile (2) | CHEMBL2420465
Type:
Small organic molecule
Emp. Form.:
C18H10N4O3
Mol. Mass.:
330.297
SMILES:
Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N
Structure:
Search PDB for entries with ligand similarity: