Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50043787
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
496±n/a nM
Citation
 Nazare, M; Halland, N; Schmidt, F; Weiss, T; Dietz, U; Hofmeister, A N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals US Patent  US9174993 Publication Date 11/3/2015 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50043787
Synonyms:
CHEMBL3356056 | US9174993, 3 | US9221828, 3
Type:
Small organic molecule
Emp. Form.:
C17H10Cl2FN5O2S
Mol. Mass.:
438.263
SMILES:
Fc1cc(ccc1NS(=O)(=O)c1cc(Cl)ccc1Cl)-c1cnc2cn[nH]c2n1
Structure:
Search PDB for entries with ligand similarity: