Reaction Details Report a problem with these data
Target
Arachidonate 15-lipoxygenase
Ligand
BDBM50092228
Substrate
n/a
Meas. Tech.
LoxA HTP Assay
Temperature
298.15±n/a K
IC50
1.62e+4± 3.1e+3 nM
Comments
extracted
Citation
Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry 55:3329-40 (2016) [PubMed] Article
More Info.:
Target
Name:
Arachidonate 15-lipoxygenase
Synonyms:
15-Lipoxygenase (LoxA)
Type:
Protein
Mol. Mass.:
74804.41
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
685
Sequence:
MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIAILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRRPYEYLLPSRIPASTNI
Inhibitor
Name:
BDBM50092228
Synonyms:
4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | 7-Cyclopentyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | CHEMBL47940 | NCGC00015280
Type:
Small organic molecule
Emp. Form.:
C23H22N4O
Mol. Mass.:
370.447
SMILES:
Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1