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Target
Arachidonate 15-lipoxygenase
Ligand
BDBM22165
Substrate
n/a
Meas. Tech.
LoxA HTP Assay
Temperature
298.15±n/a K
IC50
8.0e+3± 1.2e+3 nM
Comments
extracted
Citation
 Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry 55:3329-40 (2016) [PubMed]  Article 
Target
Name:
Arachidonate 15-lipoxygenase
Synonyms:
15-Lipoxygenase (LoxA)
Type:
Protein
Mol. Mass.:
74804.41
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
685
Sequence:
MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNLAGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNFVASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIAILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVAGPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAVDKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMAKTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGAARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPYRDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQLVEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTLVALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATIRTRNQARRRPYEYLLPSRIPASTNI
  
Inhibitor
Name:
BDBM22165
Synonyms:
1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine | CHEMBL153260 | CHEMBL281594 | CHEMBL542933 | CHEMBL543876 | GBR 12909 | GBR-12909 | NCGC00015300 | US9944618, Compound ID No. 175 | Vanoxerine
Type:
Small organic molecule
Emp. Form.:
C28H32F2N2O
Mol. Mass.:
450.5633
SMILES:
Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1
Structure:
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