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Target
Casein kinase I isoform delta
Ligand
BDBM191583
Substrate
n/a
Meas. Tech.
KinaseGlo Plus Luminescent Assay
pH
7.5±n/a
IC50
3.57e+4± 5.2e+3 nM
Comments
extracted
Citation
 Ursu, A; Illich, DJ; Takemoto, Y; Porfetye, AT; Zhang, M; Brockmeyer, A; Janning, P; Watanabe, N; Osada, H; Vetter, IR; Ziegler, S; Schöler, HR; Waldmann, H Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol 23:494-507 (2016) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM191583
Synonyms:
6-(2,6-difluorophenyl)pteridine-2,4,7-triamine (27)
Type:
Small organic molecule
Emp. Form.:
C12H9F2N7
Mol. Mass.:
289.2436
SMILES:
Nc1nc(N)c2nc(c(N)nc2n1)-c1c(F)cccc1F |(-9.6,-2.37,;-8.26,-1.6,;-8.26,-.06,;-6.93,.72,;-6.93,2.26,;-5.6,-.06,;-4.26,.71,;-2.93,-.06,;-2.93,-1.6,;-1.6,-2.37,;-4.26,-2.37,;-5.6,-1.6,;-6.93,-2.37,;-1.6,.71,;-1.6,2.25,;-2.93,3.02,;-.26,3.02,;1.07,2.25,;1.07,.71,;-.26,-.06,;-.26,-1.6,)|
Structure:
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