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Target
Transient receptor potential cation channel subfamily V member 3
Ligand
BDBM191696
Substrate
n/a
Meas. Tech.
Radiometric Calcium Assay
Temperature
303.15±n/a K
IC50
>10000±n/a nM
Comments
extracted
Citation
 Khairatkar-Joshi, N; Kulkarni, A; Mukhopadhyay, I; Kattige, VG; Bhosale, VM; Wale, DP; Thomas, A; Kumar, S; Chaudhari, SS Treatment of respiratory disorders using TRPA1 antagonists US Patent  US9186360 Publication Date 11/17/2015 
Target
Name:
Transient receptor potential cation channel subfamily V member 3
Synonyms:
TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3
Type:
Enzyme
Mol. Mass.:
90635.51
Organism:
Homo sapiens (Human)
Description:
Q8NET8
Residue:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
  
Inhibitor
Name:
BDBM191696
Synonyms:
US9186360, 40
Type:
Small organic molecule
Emp. Form.:
C23H25F2N6O4S
Mol. Mass.:
519.544
SMILES:
Cn1c2c[nH]n(CC(=O)Nc3nc(cs3)-c3cc(F)c(OCC(C)(C)C)c(F)c3)c2c(=O)n(C)c1=O
Structure:
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