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Target
Cytochrome b
Ligand
BDBM192008
Substrate
n/a
Meas. Tech.
Cytochrome b Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol 23:978-991 (2016) [PubMed]  Article 
Target
Name:
Cytochrome b
Synonyms:
COB | CYB_HUMAN | CYTB | MT-CYB | MTCYB
Type:
Protein
Mol. Mass.:
42724.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
380
Sequence:
MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA
  
Inhibitor
Name:
BDBM192008
Synonyms:
Antimycin A | [(2R,3S,6S,7R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
Type:
Small organic molecule
Emp. Form.:
C28H40N2O9
Mol. Mass.:
548.6252
SMILES:
CCCCCCC1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O
Structure:
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