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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM192574
Substrate
n/a
Meas. Tech.
PIM Enzyme Assay
IC50
0.3±n/a nM
Citation
 D'amico, DC; Herberich, BJ; Jackson, CL; Pettus, LH; Tasker, A; Wang, H; Wu, B; Wurz, R Bicyclic pyridazine compounds as Pim inhibitors US Patent  US9187486 Publication Date 11/17/2015 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM192574
Synonyms:
US9187486, 37 | US9187486, 39 | US9187486, 60
Type:
Small organic molecule
Emp. Form.:
C23H23F2N7
Mol. Mass.:
435.4724
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r|
Structure:
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