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Target
Serine/threonine-protein kinase SIK2
Ligand
BDBM192713
Substrate
n/a
Meas. Tech.
Caliper-based Mobility Shift Assay
pH
8±n/a
IC50
19.5±0.6 nM
Comments
extracted
Citation
 Sundberg, TB; Liang, Y; Wu, H; Choi, HG; Kim, ND; Sim, T; Johannessen, L; Petrone, A; Khor, B; Graham, DB; Latorre, IJ; Phillips, AJ; Schreiber, SL; Perez, J; Shamji, AF; Gray, NS; Xavier, RJ Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol 11:2105-11 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase SIK2
Synonyms:
KIAA0781 | QIK | SIK2 | SIK2_HUMAN | SNF1LK2 | Salt-inducible kinase 2 (SIK2) | Serine/threonine-protein kinase SIK2
Type:
Protein
Mol. Mass.:
103906.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
926
Sequence:
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
  
Inhibitor
Name:
BDBM192713
Synonyms:
HG-9-91-01 derivative, 2
Type:
Small organic molecule
Emp. Form.:
C32H34ClN7O3
Mol. Mass.:
600.11
SMILES:
COc1ccc(N2C(=O)N(Cc3cnc(Nc4ccc(cc4)N4CCN(C)CC4)nc23)c2c(C)cccc2Cl)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: