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Target
Serine/threonine-protein kinase SIK2
Ligand
BDBM192717
Substrate
n/a
Meas. Tech.
Caliper-based Mobility Shift Assay
pH
8±n/a
IC50
150±20 nM
Comments
extracted
Citation
 Sundberg, TB; Liang, Y; Wu, H; Choi, HG; Kim, ND; Sim, T; Johannessen, L; Petrone, A; Khor, B; Graham, DB; Latorre, IJ; Phillips, AJ; Schreiber, SL; Perez, J; Shamji, AF; Gray, NS; Xavier, RJ Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol 11:2105-11 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase SIK2
Synonyms:
KIAA0781 | QIK | SIK2 | SIK2_HUMAN | SNF1LK2 | Salt-inducible kinase 2 (SIK2) | Serine/threonine-protein kinase SIK2
Type:
Protein
Mol. Mass.:
103906.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
926
Sequence:
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDAVDPQHNGYVLVN
  
Inhibitor
Name:
BDBM192717
Synonyms:
HG-9-91-01 derivative, 6
Type:
Small organic molecule
Emp. Form.:
C33H36ClN7O3
Mol. Mass.:
614.137
SMILES:
CCOc1cc(ccc1Nc1ncc2CN(C(=O)N(c3ccc(OC)cn3)c2n1)c1c(C)cccc1Cl)C1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: