Reaction Details Report a problem with these data
Target
Interleukin-10
Ligand
BDBM192713
Substrate
n/a
Meas. Tech.
AlphaLISA-based IL-10 Detection
EC50
3±n/a nM
Citation
 Sundberg, TB; Liang, Y; Wu, H; Choi, HG; Kim, ND; Sim, T; Johannessen, L; Petrone, A; Khor, B; Graham, DB; Latorre, IJ; Phillips, AJ; Schreiber, SL; Perez, J; Shamji, AF; Gray, NS; Xavier, RJ Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol 11:2105-11 (2016) [PubMed]  Article 
Target
Name:
Interleukin-10
Synonyms:
IL10 | IL10_HUMAN | Interleukin-10 (IL-10)
Type:
Protein
Mol. Mass.:
20520.59
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
178
Sequence:
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
  
Inhibitor
Name:
BDBM192713
Synonyms:
HG-9-91-01 derivative, 2
Type:
Small organic molecule
Emp. Form.:
C32H34ClN7O3
Mol. Mass.:
600.11
SMILES:
COc1ccc(N2C(=O)N(Cc3cnc(Nc4ccc(cc4)N4CCN(C)CC4)nc23)c2c(C)cccc2Cl)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: