Reaction Details Report a problem with these data
Target
Beta-glucuronidase
Ligand
BDBM193662
Substrate
n/a
Meas. Tech.
β-Glucuronidase assay
IC50
8.816e+4± 1.56e+3 nM
Citation
 Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Al Muqarrabin, LM; Zaki, HM; Ahmat, N; Nasir, A; Khan, F Synthesis of novel disulfide and sulfone hybrid scaffolds as potent ß-glucuronidase inhibitor. Bioorg Chem 68:15-22 (2016) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB
Type:
Protein
Mol. Mass.:
74467.69
Organism:
Bos taurus (Bovine)
Description:
EC 3.2.1.31, bovine liver
Residue:
652
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
  
Inhibitor
Name:
BDBM193662
Synonyms:
N,N'-(disulfanediylbis(2,1-phenylene))bis(3-bromobenzenesulfonamide) (9)
Type:
Small organic molecule
Emp. Form.:
C24H18Br2N2O4S4
Mol. Mass.:
686.479
SMILES:
Brc1cccc(c1)S(=O)(=O)Nc1ccccc1SSc1ccccc1NS(=O)(=O)c1cccc(Br)c1
Structure:
Search PDB for entries with ligand similarity: