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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM193848
Substrate
n/a
Meas. Tech.
ALR2 in vitro Inhibition Assay
IC50
1.2e+2± 5e+1 nM
Citation
 Ibrar, A; Tehseen, Y; Khan, I; Hameed, A; Saeed, A; Furtmann, N; Bajorath, J; Iqbal, J Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors. Bioorg Chem 68:177-186 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM193848
Synonyms:
Coumarin-thiazole series I, 6a
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2S
Mol. Mass.:
361.417
SMILES:
C\C(=N/Nc1nc(cs1)-c1cc2ccccc2oc1=O)c1ccccc1
Structure:
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