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Target
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Ligand
BDBM194494
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
1300±100 nM
Comments
extracted
Citation
 De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent  US9200020 Publication Date 12/1/2015 
Target
Name:
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms:
HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ
Type:
Protein
Mol. Mass.:
26352.14
Organism:
Plasmodium falciparum
Description:
P20035
Residue:
231
Sequence:
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
  
Inhibitor
Name:
BDBM194494
Synonyms:
US9200020, Table 3 compound 3
Type:
Small organic molecule
Emp. Form.:
C14H24N6O6P
Mol. Mass.:
403.3507
SMILES:
COC(=O)CCCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Structure:
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