Reaction Details
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Hypoxanthine phosphoribosyltransferase
Ligand
BDBM194492
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
1500±400 nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 More Info.:
Target
Name:
Hypoxanthine phosphoribosyltransferase
Synonyms:
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Enzyme
Mol. Mass.:
26972.31
Organism:
Plasmodium vivax
Description:
A0A0J9TE27
Residue:
233
Sequence:
MKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSYCNDQSLDRIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRTAPPTA
Inhibitor
Name:
BDBM194492
Synonyms:
US9200020, Table 3 compound 1
Type:
Small organic molecule
Emp. Form.:
C13H22N6O6P
Mol. Mass.:
389.3241
SMILES:
CCOC(=O)CN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O
Structure:
