Reaction Details
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Report a problem with these dataTarget
Hypoxanthine phosphoribosyltransferase
Ligand
BDBM60890
Substrate
n/a
Meas. Tech.
Growth Inhibition Assay
Temperature
310.15±n/a K
Ki
700±60 nM
Comments
extracted
Citation
De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 More Info.:
Target
Name:
Hypoxanthine phosphoribosyltransferase
Synonyms:
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Enzyme
Mol. Mass.:
26972.31
Organism:
Plasmodium vivax
Description:
A0A0J9TE27
Residue:
233
Sequence:
MKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTESPKHLYVEHYVRVKSYCNDQSLDRIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEYLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKFRDLDHLCLVNDEGIKKFRTAPPTA
Inhibitor
Name:
BDBM60890
Synonyms:
US9200020, Table 3 compound 5B
Type:
n/a
Emp. Form.:
C12H18N6O4P
Mol. Mass.:
341.2829
SMILES:
OP(O)(=O)CCN(CCC#N)CCn1c[nH]c2c1nc[nH]c2=O
Structure:
