Reaction Details Report a problem with these data
Target
Xanthine-guanine phosphoribosyltransferase
Ligand
BDBM194504
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
27000±n/a nM
Comments
extracted
Citation
 De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent  US9200020 Publication Date 12/1/2015 
Target
Name:
Xanthine-guanine phosphoribosyltransferase
Synonyms:
XGPT_ECOLI | Xanthine phosphoribosyltransferase (XGPRT) | gpp | gpt | gxu
Type:
Enzyme
Mol. Mass.:
16968.37
Organism:
Escherichia coli (strain K12)
Description:
P0A9M5
Residue:
152
Sequence:
MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPISGR
  
Inhibitor
Name:
BDBM194504
Synonyms:
US9200020, 2
Type:
Small organic molecule
Emp. Form.:
C10H18N6O7P2
Mol. Mass.:
396.2334
SMILES:
Nc1nc2n(CCN(CCP(O)(O)=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Structure:
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