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Target
Bcl2-associated agonist of cell death
Ligand
BDBM50424725
Substrate
n/a
Meas. Tech.
Bak Peptide Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1100±n/a nM
Comments
extracted
Citation
 Chen, CH; Chen, Z; Fortanet, JG; Grunenfelder, D; Karki, R; Kato, M; LaMarche, MJ; Perez, LB; Stams, TM; Williams, S 1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2 US Patent  US10093646 Publication Date 10/9/2018 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50424725
Synonyms:
CHEMBL2314177 | US10093640, Example 5 | US10844032, Example 5
Type:
Small organic molecule
Emp. Form.:
C22H17ClO3S
Mol. Mass.:
396.887
SMILES:
OC(=O)c1sc2cc(Cl)ccc2c1CCCOc1cccc2ccccc12
Structure:
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